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Dr. Samanta's
Research Group

Research Works

Dr. Samanta's
Research Group

Research Works

WORK AT A GLANCE

Research Interest

1. Understanding the molecular mechanisms of antibiotics resistance developed by bacteria in biofilm

2. Development of advanced nano-scale materials to treat bacterial biofilm infections.

3. In silico approach to find potent drug molecules for treatment of small cell lung cancer (SCLC).



INTERESTED PhD or Post-Doc STUDENTS CAN CONTACT ME.


GROUP MEMBERS

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Dr. Sintu Kumar Samanta

(Group Mentor)

Assistant Professor,
Department of Applied Sciences, (Go To Department)
Indian Institute of Information Technology, Allahabad. (Go To Homepage)
Email: samantasintu@iiita.ac.in
Phone: 0532-292 2426
Google Scholar     Research Gate

ON GOING PhD STUDENTS




Post-Doctoral Fellow (Alumni)




ALUMNI

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Mr. Ankit Porwal

(2017)

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Ms. Prerna Pant

(2017)

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Ms. Debjani Banerjee

(2018)

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Ms. Aprajita Basu

(2018)

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Ms. Anamika Jaiswal

(2018)

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Mr. Shubham Saxena

(2018)

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Mr. Puneet Kumar

(2018)

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Ms. Uzini Devi Diamary

(2019)

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Ms. Anam Tanveer

2020, Integral University, Lucknow (Intern)

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Mr. Jagannath Pathy

2020, Integral University, Lucknow (Intern)


TEACHING WORKS

• OMICS I (1st sem. M. Tech. and 7th sem. Dual degree Bioinformatics)



• System Biology (3rd sem. M. Tech. Bioinformatics)



• Engineering Biology (6th sem. B. Tech. Information Technology)



• Bioinformatics (7th sem. B. Tech. Information Technology)




RESEARCH WORKS

Journal Publications


21) Anirudh Singh, Arushi Verma, Ruhar Singh, Amaresh Sahoo, Sintu Kumar Samanta. 2020. Combination therapy of biogenic C-dots and lysozyme for enhanced antibacterial and antibiofilm activity. Nanotechnology. doi: 10.1088/1361-6528/abc2ed.

20) Arushi Verma, Saurabh Shivalkar, Md Palashuddin Sk, Sintu Kumar Samanta, Amaresh K Sahoo. 2020. Nanocomposite of Ag NPs and Catalytic Fluorescent C-dots for Synergistic Bactericidal Activity through Enhanced ROS Generation. Nanotechnology. 2;31(40):405704. doi:10.1088/1361-6528/ab996f.

19) Anirudh Singh, Pavan Kumar Gautam, Arushi Verma, Vishal Singh, Pingali M. Shivapriya, Saurabh Shivalkar, Amaresh Kumar Sahoo, Sintu Kumar Samanta. 2020. Green synthesis of metallic nanoparticles as effective alternatives to treat antibiotics resistant bacterial infections: A review. Biotechnology Reports, 25:e00427. doi: 10.1016/j.btre.2020.e00427.

18) Sintu Kumar Samanta, Priyanka Biswas, Arka Banerjee, Avipsa Bose, Nida Siddiqui, Subhalaxmi Nambi, Deepak Kumar Saini, Sandhya S Visweswariah. 2019. A universal stress protein in Mycobacterium smegmatis sequesters the cAMP-regulated lysine acyltransferase and is essential for biofilm formation. Journal of Biological Chemistry, 295(6):1500-1516.

17) Arushi Verma, Farwa Arshad, Kafeel Ahmad, Upashi Goswami, Sintu Kumar Samanta, Amaresh Kumar Sahoo, Md Palashuddin Sk. 2019. Role of surface charge in enhancing antibacterial activity of fluorescent carbon dots. Nanotechnology, 8;31(9):095101. doi: 10.1088/1361-6528/ab55b8.

16) Pavan K. Gautam, Pingali M. Shivapriya, Sushmita Banerjee, Amaresh K. Sahoo, Sintu Kumar Samanta. 2019. Biogenic fabrication of iron nanoadsorbents from mixed waste biomass for aqueous phase removal of alizarin red S and tartrazine: Kinetics, isotherm, and thermodynamic investigation. Environmental Progress & Sustainable Energy. doi: 10.1002/ep.13326.

15) Vishal Singh, Aparajita Basu, Pingali M. Shivapriya, Pritish Kumar Varadwaj, Sintu Kumar Samanta, Amaresh Kumar Sahoo. 2019. Exploration of interactions of ‘blood-nano interface’ of carbon-based nanomaterials for biomedical applications. Journal of Materials Research, 34(11), 1950-1964. doi:10.1557/jmr.2019.176.

14) Debjani Banerjee, Pingali M. Shivapriya, Pavan Kumar Gautam, Krishna Misra, Amaresh Kumar Sahoo, Sintu Kumar Samanta. 2019. A Review on Basic Biology of Bacterial Biofilm Infections and Their Treatments by Nanotechnology-Based Approaches. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. https://doi.org/10.1007/s40011-018-01065-7.

13) Pavan Kumar Gautam, Anirudh Singh, Krishna Misra, Amaresh Kumar Sahoo, Sintu Kumar Samanta. 2019. Synthesis and applications of biogenic nanomaterials in drinking and wastewater treatment. Journal of Environmental Management, 231:734-748.

12) Paulomi Ghosh, Arun Prabhu Rameshbabu, Dipankar Das, Bhuvaneshwaran Subramanian, Sintu Kumar Samanta, Sabyasachi Roy, Sagar Pal, Sudip Kumar Ghosh, Santanu Dhara. 2018. Single-pot biofabrication of living fibers for tissue engineering applications. Journal of Materials Research, 33(14):2019-2028. doi:10.1557/jmr.2018.143

11) Sintu Kumar Samanta, Sneha Susan Varghese, Deepak Krishnan, Mithu Baidya, Digant Nayak, Sumanta Mukherjee, Sudip K Ghosh. 2018. A novel encystation specific protein kinase regulates chitin synthesis in Entamoeba invadens. Molecular and Biochemical Parasitology, 220:19-27.

10) Sintu Kumar Samanta, Albel Singh, Priyanka Biswas, Apoorva Bhatt, Sandhya S Visweswariah. 2017. Mycobacterial phenolic glycolipid synthesis is regulated by cAMP-dependent lysine acylation of FadD22. Microbiology, 163(3):373-382.

9) Atanu Singha Roy, Sintu Kumar Samanta, Pooja Ghosh, Debi Ranjan Tripathy, Sudip Kumar Ghosh, Swagata Dasgupta. 2016. Cell cytotoxicity and serum albumin binding capacity of the morin-Cu(II) complex and its effect on deoxyribonucleic acid. Mol. BioSyst, 12(9), 2818-2833.

8) Atanu Singha Roy, Debi Ranjan Tripathy, Sintu Kumar Samanta, Sudip K. Ghosh, Swagata Dasgupta. 2016. DNA damaging, cell cytotoxicity and serum albumin binding efficacy of the rutin–Cu(II) complex. Mol. BioSyst, 12(5), 1687-1701.

7) Anshika Singhal, Gunjan Arora, Richa Virmani, Parijat Kundu, Tanya Khanna, Andaleeb Sajid, Richa Misra, Jayadev Joshi, Vikas Yadav, Sintu Kumar Samanta, Neeru Saini, Amit K Pandey, Sandhya S Visweswariah, Christian Hentschker, Dörte Becher, Ulf Gerth, Yogendra Singh. 2015. Systematic analysis of mycobacterial acylation reveals first example of acylation-mediated regulation of enzyme activity of a bacterial phosphatase. Journal of Biological Chemistry, 290(43):26218-26234.

6) Partha Laskar, Sintu Kumar Samanta, Sudip Kumar Ghosh, Joykrishna Dey. 2014. In vitro evaluation of pH-sensitive cholesterol-containing stable polymeric micelles for delivery of camptothecin. Journal of Colloid and Interface Science, 430:305-314.

5) Chinmoy Manna, Sintu Kumar Samanta, Sudip Kumar Ghosh, Tanmaya Pathak. 2013. Synthesis of 1,8-dioxooctahydroxanthene C-nucleosides. Tetrahedron Letters, 54(30):3971-3973.

4) Pallab Datta, Paulomi Ghosh, Kuntal Ghosh, Pritiprasanna Maity, Sintu Kumar Samanta, Sudip Kumar Ghosh, Pradeep Kumar Das Mohapatra, Jyotirmoy Chatterjee, Santanu Dhara. 2013. In vitro ALP and Osteocalcin gene expression analysis and in vivo biocompatibility of N-methylene phosphonic chitosan nanofibers for bone regeneration. Journal of Biomedical nanotechnology, 9(5):870-879.

3) Sintu Kumar Samanta, Sudip K Ghosh. 2012. The chitin biosynthesis pathway in Entamoeba and the role of Glucosamine-6-P isomerase by RNA interference. Molecular and Biochemical Parasitology, 186(1):60-68.

2) Sintu Kumar Samanta, Soumyendu Mehra, T. K. Maiti, Pramit Ghosh, Sudip K. Ghosh. 2012. Socio-demographic correlates influencing the trend of intestinal parasitic infestation in a rural community of West Bengal, India. Journal of Public Health, 20:405-412.

1) Sintu Kumar Samanta, Soumyendu Mehra, T. K. Maiti, Pramit Ghosh, Sudip K. Ghosh. 2012. A community based epidemiological study on intestinal amoebiasis in rural West Bengal, India. Asian Journal of Medical Sciences, 2(3):164-168.


Conference Publications


1. Aparajita Basu, Ananya Mishra, Divya Maheshwari, Shruti Gupta, Shubham Saxena, Amaresh Kumar Sahoo, Sintu Kumar Samanta. 2017. Study of antibacterial activity of Cu NPs and fluorescent C-Dots based nano-gel. Journal of Nanoscience, Nanoengineering & Applications, 7(3):1-5.


Conferences Attended


16. Partha Laskar, Sintu Kumar Samata, Sudip Kumar Ghosh, Joykrishna Dey. “Dual stimuli-responsive hydrophobically modified amphiphilic copolymers for encapsulation and sustained release of Camptothecine”. Conference on Photochemistry & Luminescence (CPL-2012), Chemistry Department, IIT Guwahati, Assam, India. March-2012 (Poster Presentation by Partha Laskar)

15. Aparajita Basu, Ananya Mishra, Divya Maheshwari, Shruti Gupta, Shubham Saxena, Amaresh Kumar Sahoo, Sintu Kumar Samanta. “Synthesis of nanocomposite of copper nanoparticles and carbon quantum dots as an antibacterial gel” International Conference on Nanotechnology: Ideas, Innovations & Initiatives-2017 organized by IIT Roorkee, Uttarakhand, India. December 06-08, 2017 (Presentation by Shruti Gupta).

14. Arushi Verma, Farwa Arshad, Kafeel Ahmad, Upashi Goswami, Sintu Kumar Samanta, Amaresh kumar Sahoo, Md Palashuddin Sheikh. “Enhanced Antibacterial Activity of Fluorescent Carbon Dots Due to Surface Charge Variation”. International Conference on Nano Science and Technology (ICONSAT-2020) organized by S.N Bose National Centre for Basic Sciences, Kolkata, India. 5-7th March, 2020 (Poster presentation by A. Verma).

13. Pingali M. Shivapriya, Amaresh Kumar Sahoo, Pritish Kumar Varadwaj, Sintu Kumar Samanta. “Targeting INSM1 in Order to Prevent the Growth of Small Cell Lung Cancer”. International Conference on Drug Discovery (ICDD) 2020, organized by BITS-Hyderabad, Hyderabad, Telangana, India. 29th February - 2nd March, 2020 (Poster presentation by Shivapriya PM).

12. Arushi Verma, Sintu Kumar Samanta, Amaresh Kumar Sahoo. “Catalytic synthesis of Ag NPs using Fluorescent Cdots for Enhanced Anti-Bacterial Activity”. International Conference on Biotechnological Interventions for Societal Development (BIOSANGAM-2020) organized by MNNIT-Allahabad, Prayagraj, UP, India. 21-23th February, 2020 (Poster presentation by A. Verma).

11. Pingali M. Shivapriya, Imlimaong Aier, Amaresh Kumar Sahoo, Pritish Kumar Varadwaj, Sintu Kumar Samanta. “Targeting transcriptional factor of the Hedgehog pathway for Pancreatic Cancer treatment”. International Conference on Biotechnological Interventions for Societal Development (BIOSANGAM-2020) organized by MNNIT-Allahabad, Prayagraj, UP, India. 21-23th February, 2020 (Poster presentation by Shivapriya PM).

10. Saurab Shivalkar, Sintu Kumar Samanta, Amaresh Kumar Sahoo. “Design and Development of autonomously driven micro-bots or nano-bots for efficient treatment of polluted water”. International Conference on Biotechnological Interventions for Societal Development (BIOSANGAM-2020) organized by MNNIT-Allahabad, Prayagraj, UP, India.21-23th February, 2020 (Poster Presentation by S. Shivalkar).

9. Anirudh Singh, Amaresh Kumar Sahoo, Sintu Kumar Samanta. “Ecofriendly synthesis of carbon dot-chitosan nano-carrier and their use for the antibacterial property”. International Conference on Recent Advances in Engineering & Science (ICRAES 2020) organized by Aligarh Muslim University, Aligarh, UP, India. 11-12th January 2020 (Oral presentation by A. Singh).

8. Arushi Verma, Sintu Kumar Samanta, Amaresh Kumar Sahoo. “Combination Therapy of Ag NPs and Fluorescent C-dots for Enhanced Anti-Bacterial Activity”. International Conference on Advanced Nanomaterial and Nanotechnology (ICANN 2019) organized by IIT Guwahati, Assam, India. 18-21th December 2019 (Poster presentation by A. Verma).

7. Pavan Kumar Gautam, Sintu Kumar Samanta. “Biogenic synthesis of magnetic nanoadsorbents and their use for the aqueous phase removal of lead”. 3rd International conference on Science and Engineering of materials (ICSEM-2019), organized by Sharda University, Greater Noida, India. 19-21th July, 2019 (Oral presentation by Dr Gautam).

6. Pavan Kumar Gautam, Sintu Kumar Samanta. “Biogenic preparation of magnetic nanoparticles and their application for the aqueous phase removal of azo dyes”. IEEE Technical Co-Sponsored International Conference on Engineering Science & Advance Research (ESAR’19) organized by Rama University, Kanpur, India. 13-15th March, 2019 (Oral presentation by Dr Gautam).

5. Sintu Kumar Samanta, Nida Siddiqui, Subhalaxmi Nambi, Ann Thomas, Sandhya S Visweswariah. “A Universal Stress Protein in M. smegmatis regulates protein acylation in mycobacteria: role in biofilm formation”. MCB75: from Molecules to Organisms, organised by Dept. of MCB, IISC Bangalore, India. 11-14th December, 2015 (Poster Presentation by SK Samanta).

4. Sintu Kumar Samanta, Biswajit Saha, Mithu Baidya, Tanya Singh, Sudip Kumar Ghosh. “Novel Encystation Specific Protein Kinase in Entamoeba invadens”. 81st Annual meeting of the Society of Biological Chemists, Kolkata, WB, India. 8-11th November, 2012 (Poster Presentation by B. Saha).

3. Sintu Kumar Samanta, Sudip Kumar Ghosh. “Chitin biosynthesis pathway in encysting Entamoeba”. EMBO Global Exchange Lecture Course & Symposium on ‘Amoebiasis: Exploring the Biology and the Pathogenesis of Entamoeba’, Khajuraho, MP, India. 4-7th March, 2012 (Poster Presentation by SK Samanta).

2. Paulomi Ghosh, Sintu Kumar Samanta, Sudip Kumar Ghosh, Santanu Dhara. “Omics in Bone Tissue Engineering”. International Conference on OMICS MEETS DISEASE and 3rd Annual Meeting of Proteomics Society (India), organized by Saha Institute of Nuclear Physics (SINP), Indian Institute of Chemical Biology (IICB) and University of Calcutta, Kolkata, WB, India. 15-18th December, 2011 (Poster Presentation by P. Ghosh).

1. Sintu Kumar Samanta, Deepak Krishnan, Biswajit Saha, Tanya Singh, Sudip Kumar Ghosh. “Encystation Biology of Entamoeba”. Research Scholars Day & Diamond Jubilee Meet- Biotechnology 2011, organised by Dept. of Biotechnology, IIT Kharagpur, WB, India. 11-12th November, 2011 (Poster Presentation by SK Samanta).


Book Chapters


2. Pavan Kumar Gautam, Saurabh Shivalkar and Sintu Kumar Samanta. 2020. Environmentally Benign Synthesis of Nanocatalysts: Recent Advancements and Applications. Springer Nature Switzerland, ISBN: 978-3-030-11155-7. pp 1-19.

1. Saurabh Shivalkar, Vishal Singh, Amaresh Kumar Sahoo, Sintu Kumar Samanta, Pavan Kumar Gautam. 2020. Bioremediation: a potential ecological tool for waste management. Elsevier, ISBN: 978-0-12-820318-7. Pp 1-15.


Patents


1. Amaresh Kumar Sahoo, Sintu Kumar Samanta, Saurabh Shivalkar, Pavan Kumar Gautam, Arushi Verma. Potato Peel based C-Dots for the development of Nanobots to degrade industrial effluents dye containing toxic dyes. Status: Filed Indian Patent. Application No. 202011049379


Sponsored Projects


2. Title: Development of kit for simultaneous isolation of viral RNA by magnetic nanoprobe and rapid detection of novel coronavirus by highly luminescent gold nanoclusters, Funding Agency: DBT, Govt. of India, Duration: 2020-2021, Sanctioned Amount: INR 14, 00,000/-, Role: Co- PI

1. Title: Development of a Novel Nanocomposite to Combat the Biofilm Infections, Funding Agency: Institute Sponsored Project by IIIT Allahabad, Duration: 2017-2019, Sanctioned Amount: INR 20, 00,000/-, Role: PI


Talks Delivered


3. “Development of an advanced nanomaterial to combat bacterial biofilm infections”, Odisha University of Agriculture and Technology, College of Basic Science and Humanities, Bhubaneswar-751003, Odisha, India, November 25, 2020.

2. “Role of a universal stress protein in the regulation of biofilm formation in M. smegmatis” at webinar on “Recent Developments from Molecular Pathogenesis to Theranostics (RDMT-2020)”, Indian Institute of Information Technology Allahabad, Uttar Pradesh, India, November 8, 2020.

1. “Strategies to combat bacterial biofilm infections: A focus on the development of an advanced nanomaterial”, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India, October 17, 2020.


BIOSKETCH

EXPERIENCES

• Assistant Professor (March 2016 – present): Department of Applied Sciences, IIIT Allahabad

• Post-Doctoral Fellow (December 2012-Feb, 2016): IISc, Bangalore India



EDUCATIONAL QUALIFICATION

Doctor of Philosophy (PhD): Indian Institute of Technology Kharagpur (2012)



AWARDS AND ACHIEVEMENTS

UGC-Dr. D. S. Kothari Post Doctoral Fellow by UGC, New Delhi, India (2013)



VISITING RESEARCHER

School of Biosciences, University of Birmingham, UK (May-June, 2014)



ASSOCIATION



Member

• Life member of "Society of Biological Chemists (India)"

• Life member of "Indian Science Congress Association"



Reviewer

• International Journal of Bioinformatics Research and Applications

• Environmental Science and Pollution Research

• Proceedings of the National Academy of Sciences, Physical Sciences (NASA)

• International Journal of Environmental Science and Technology

• Journal of Nanostructure in Chemistry (JNSC)



Collaborators

• Prof Sudip. K. Ghosh, IIT Kharagpur

• Dr. Atanu Singha Roy, NIT Meghalaya

• Dr. Md Palashuddin Sk, Aligarh Muslim University

• Dr Amaresh Sahoo, IIIT Allahabad



Events Organized

3. Title: “Recent Developments from Molecular Pathogenesis to Theranostics (RDMT-2020)”, Type: Webinar, Organizer: Dept. of Applied Sciences, IIIT Allahabad, Duration: 7-8th November, 2020, Role: Convener.

2. Title: “Materials-Studio”, Type: Online Workshop, Organizer: Dept. of Applied Sciences, IIIT Allahabad, Duration: 6th July, 2020, Role: Convener.

1. Title: “Recent Developments in Applied Biotechnology (RDAB-2020)”, Type: National seminar cum workshop, Organizer: Dept. of Applied Sciences, IIIT Allahabad, Duration: 6-8th March, 2020, Role: Convener.


CONTACT DETAILS