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Biochemistry & Bioinformatics Lab
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<div>Indian Institute of Information Technology, Allahabad</div>
<div>भारतीय सूचना प्रौद्योगिकी संस्थान, इलाहाबाद</div>
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Welcome to Dr. Samanta's Research Group
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Research Theme</div>
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Antimicrobial resistance (AMR) is rapidly escalating, posing a significant global health challenge. Microbial
infections, particularly those caused by multidrug-resistant (MDR) pathogens like the ESKAPE group, are
increasingly threatening human health, especially in regions with inadequate antibiotic regulation.
Projections suggest that AMR-related deaths could surpass those from cancer by 2050. Biofilm-associated
infections further complicate treatment, as cells in biofilm exert nearly thousand fold more resistance to
antibiotics as compared to planktonic cells. Addressing this crisis requires novel approaches, such as
exploring naturally occurring antimicrobial peptides (AMPs). These short peptides, integral to innate immunity
across various organisms, can offer as potent alternatives to traditional antibiotics. Unlike single-target
antibiotics, AMPs often have multiple mechanisms of action, reducing the likelihood of resistance development.
We aim to indentify the broad-spectrum antibacterial and antibiofilm AMPs against critical priority pathogens
like carbapenem resistant <i>Pseudomonas aeruginosa</i>. To achieve our following objectives, we perform both <i>in
silico</i> predictions as well as wet laboratory validation in both planktonic and biofilm state of the
pathogen.
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Research Objectives</div>
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<div>1. Identification of naturally occurring AMPs as effective antibacterial, antibiofilm, and anti-inflammatory agents against ESKAPE pathogens.</div>
<div>2. Design and optimization of novel peptides for enhanced antibacterial potency.
</div>
<div>3. Database development of manually curated peptides against various pathogens.</div>
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In a recent study, we were able to identify potent AMPs released by human microbiome which can target
bacterial DNA, leading to cell death.<sup>5</sup> After a lot of efforts, we were able to develop databases of
manually
curated peptides to support research in AMPs.<sup>3, 4</sup> In another study, we have shown how peptides
containing
lysine and arginine repeats can affect the binding of peptides to Beta-lactamases.<sup>1</sup> One of our
articles works
as a guide to screening and selection of suitable AMPs against MDR bacteria.<sup>2</sup>
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References</div>
<div style="margin-top: 0.5%; margin-left: 2.5%; margin-right: 2.5%;">
<div>1. Anurag Anand et al. (2024). <b style="font-weight: 500;"><i>International Journal of Peptide Research
and Therapeutics</i></b>. 30, 41. DOI: <a class="bb" style="text-decoration: none;"
href="https://doi.org/10.1007/s10989-024-10619-5">10.1007/s10989-024-10619-5</a>.</div>
<div>2. Anurag Anand et al. (2023). <b style="font-weight: 500;"><i>Critical Reviews in Microbiology</i></b>.
1-20. DOI: <a class="bb" style="text-decoration: none;"
href="https://doi.org/10.1080/1040841X.2023.2293019">10.1080/1040841X.2023.2293019</a>.</div>
<div>3. Mondal et al. (2024). <b style="font-weight: 500;"><i>International Journal of Peptide Research and
Therapeutics</i></b>. 30 (36). DOI: <a class="bb" style="text-decoration: none;"
href="https://doi.org/10.1007/s10989-024-10610-0">10.1007/s10989-024-10610-0</a>.</div>
<div>4. Mondal et al. (2023). <b style="font-weight: 500;"><i>Scientific Reports</i></b>. 13:17843. DOI: <a
class="bb" style="text-decoration: none;"
href="https://doi.org/10.1038/s41598-023-45016-3">10.1038/s41598-023-45016-3</a>.</div>
<div>5. Singh et al. (2023). <b style="font-weight: 500;"><i>ACS Applied Bio Materials</i></b>. 6(9),
36743682. DOI: <a class="bb" style="text-decoration: none;"
href="https://doi.org/10.1021/acsabm.3c00302">10.1021/acsabm.3c00302</a>.</div>
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<div style="font-size: larger; color: #9A3863; font-weight:500;" class="mb-2">Also read our latest articles
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